Mediators of Inflammation
Volume 11 (2002), Issue 2, Pages 95-98
http://dx.doi.org/10.1080/09629350220131944
Levels of soluble ICAM-1 in premature and full-term neonates with infection
1Neonatology Department, State Maternity Hospital Alexandra, Athens, Greece
2Department of Pediatric Haematology-Oncology, University Hospital of Heraklion, University of Crete, Medical School, PO Box 1393, Crete, Heraklion, Greece
Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has been examined in recent studies as an early marker of neonatal infection with controversial results.
Aim: Assessment of sICAM-1 concentrations and correlation with CRP, which is the currently used marker of infection, in order to use sICAM as an early diagnostic tool in neonates suspected for infection
Methods: Blood samples and blood cultures were obtained from two groups of pre-term and full-term neonates with clinical suspicion of infection prior to the initiation of antibiotics. The sICAM-1 and CRP values were compared with the corresponding non-infected ones (n = 10 each).
Results: The sICAM-1 levels were found increased in the group of both premature and term neonates with infection compared with the corresponding healthy ones (
Conclusions: Increased sICAM-1 levels can be detected early in both full-term and premature neonates with sepsis while CRP levels are within normal range at the sametime. Assessment of sICAM-1 concentrationsmay be used as a diagnostic tool in neonates suspected for infection, resulting in earlier initiation of antibiotic therapy and therefore improving their outcome.