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Mediators of Inflammation
Volume 12, Issue 4, Pages 247-249
http://dx.doi.org/10.1080/09629350310001599693

Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

1Division and School of Allergy and Clinical Immunology, Department of Human Pathology, University of Messina, Italy
2School of Pharmacy, Department of Farmaco-Biologico, University of Messina, Italy
3Chair of Immunopathology, Department of Human Pathology, University of Messina, Italy
4Paediatric Immunology and Genetics Operative Unit, University of Messina, Italy
5IRCCS-CSS San Giovanni Rotondo, CSS-Mendel, Rome, Italy
6Dipartimento di Scienze Pediatriche Mediche e Chirurgiche, Policlinico Universitario, Padiglione NI, Messina 98125, Italy

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several candidacidal mechanisms, including oxygen-dependent killing mechanisms, mediated by a superoxide anion radical myeloperoxidase-H2O2-halide system, and reactive nitrogen intermediates. We analyzed protein carbonyl groups (considered a useful marker of oxidative stress) in the serum of patients belonging to a five-generation Italian family with an isolated form of FCNC.

Serum protein carbonyl groups in FCNC patients were significantly lower than those measured in healthy donors.

Also, if this hypothesis is merely speculative, we could suggest that the decreased circulating level of protein carbonyl groups in these patients is not a marker of a lower oxidative stress condition, but might be linked to a lower protease activity.