Yves Denizot, Eric Liozon, Laurence Guglielmi, Kim Ly, Pascale Soria, Véronique Loustaud, Elisabeth Vidal, Marie Odile Jauberteau, "No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis", Mediators of Inflammation, vol. 12, Article ID 657218, 5 pages, 2003. https://doi.org/10.1080/0962935031000097718
No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis
Background: Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases.Aims: In this study, we ensured the role of PAF in SLE patients without renal complications.Methods: Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A2, and the presence of antibodies against PAF were investigated in 17 SLE patients without active nephritis and in 17 healthy controls.Results: Blood PAF levels were not different between SLE patients (6.7±2.8 pg/ml) and healthy subjects (9.6±3.1 pg/ml). Plasma acetylhydrolase activity (the PAF-degrading enzyme) was significantly elevated in SLE patients (57.8±6.4 nmol/min/ml) as compared with controls (37.9±2.6 nmol/min/ml). Plasma soluble phospholipase A2 (the key enzyme for PAF formation) was not different between SLE patients (59.1±5.1 U/ml) and controls (54.7±2.4 U/ml). Antibodies against PAF were detected only in 3/17 SLE patients. Flow cytometry analysis did not highlight PAF receptors on circulating leukocytes of SLE patients.Conclusion: This clinical study highlights no evidence for a putative important role of PAF in SLE patients without active nephritis.
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