Mediators of Inflammation

Mediators of Inflammation / 2003 / Article

Open Access

Volume 12 |Article ID 807024 |

Anna Wozniacka, Anna Sysa-Jedrzejowska, Ewa Robak, Zbigniew Samochocki, Malgorzata Zak-Prelich, "Allergic diseases, drug adverse reactions and total immunoglobulin E levels in lupus erythematosus patients", Mediators of Inflammation, vol. 12, Article ID 807024, 5 pages, 2003.

Allergic diseases, drug adverse reactions and total immunoglobulin E levels in lupus erythematosus patients


Background: The association of allergic diseases, drug adverse reactions and elevated total immunoglobulin E (IgE) concentration in systemic lupus erythematosus patients remains controversial. The aim of the study was to investigate the prevalence of those features in active and inactive systemic lupus erythematosus patients, and in the control group as well.Methods: Total IgE concentration was evaluated by enzyme-linked immunosorbent assayResults and conclusions: The results of our study revealed that concomitant allergic diseases were not more frequent in systemic lupus erythematosus patients than in the general population. Total IgE concentration was significantly higher during the active stage of the disease. Drug reactions were very frequent but not connected with IgE elevation. Our results indicate that IgE may play a role in lupus pathogenesis, especially in the active phase of the disease.

Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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