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Mediators of Inflammation
Volume 13, Issue 1, Pages 53-54

Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer

1UMR CNRS 6101, Laboratoire d’immunologie, Faculté de Médecine, 2 rue Dr. Marcland, Limoges 87025, France
2Service de Chirurgie Digestive, Endocrinienne et Générale, 2 avenue M. Luther King, Limoges 87025, France

Received 24 November 2003; Accepted 1 December 2003

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.