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Mediators of Inflammation
Volume 13 (2004), Issue 5-6, Pages 321-325
http://dx.doi.org/10.1080/09629350400008828

Leptin levels in obese women with and without type 2 diabetes mellitus

1Department of Internal Medicine, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras 46050, Turkey
2Department of Biochemistry and Clinical Biochemistry, Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
3Department of Cardiology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras 46050, Turkey

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

INTRODUCTION: The role of leptin has been more clear in the endocrinology area after the discovery of its secretion from the adipose tissue. The aim of the study is to investigate the leptin levels in obese women in whom type 2 diabetes mellitus were present or absent.

Materials and methods: Thirty-five obese women with type 2 diabetes mellitus (group 1) and 34 obese women without type 2 diabetes mellitus (group 2) were enrolled in the study. In both groups the body mass index (BMI), waist circumference, and waist-to-hip ratio were measured. Leptin, HbA1c, creatinine and the lipid profile were assessed.

Results: Leptin was found to be statistically significantly lower in group 1 than in group 2 (40.22±17.77 ng/ml versus 50.12±15.51 ng/ml, respectively; p=0.019). It was well correlated with BMI in group 1 (r=0.60, p=0.0001). In group 1 also, correlation of leptin was moderate with creatinine and high-density lipoprotein-cholesterol (r=0.36, p=0.037 versus r=0.37, p=0.027, respectively), whereas triglyceride had a negative correlation (r=-0.34, p=0.046). In group 2, the only significant correlation with leptin was BMI (r=0.41, p=0.02). Leptin was also significantly lower in 17 subjects with poorly controlled diabetes mellitus than in 18 well-controlled diabetics (33.54±15.82 ng/ml versus 44.61±17.54 ng/ml, respectively; p=0.038).

Conclusion: Since leptin is lower in obese women with diabetes than without diabetes and additionally it is even lower in the poorly controlled diabetes subgroup, we think that further studies are required to make clear the issue for lower leptin levels, whether it is a reason or an outcome.