Mediators of Inflammation

Mediators of Inflammation / 2004 / Article

Open Access

Volume 13 |Article ID 569097 | https://doi.org/10.1080/09629350410001688549

Remzi Altin, Levent Kart, İshak Tekin, Ferah Armutcu, Meltem Tor, Tacettin Örnek, "The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis", Mediators of Inflammation, vol. 13, Article ID 569097, 5 pages, 2004. https://doi.org/10.1080/09629350410001688549

The presence of promatrix metalloproteinase-3 and its relation with different categories of coal workers' pneumoconiosis

Abstract

Extracellular matrix formation (ECM) and remodeling are critical events related to the pathogenesis of pulmonary fibrosis. Matrix metalloproteinases play an essential role in degrading and remodeling the ECM. In this study, we tried to show the presence and correlation of promatrix metalloproteinase-3 (proMMP-3) (the inactive form of metalloproteinase-3) levels in coal workers' pneumoconiosis (CWP) with different categories.The study population consisted of 44 coal miners with CWP (pos CWP). Coal miners without CWP (neg CWP, n=24) and non-underground personnel (controls, n=17) were taken as controls. All coal miners were stable and had no systemic infection or disease. Standard posterio-anterior chest radiographs and pulmonary function tests were performed to exclude any diseases other than CWP. Serum proMMP-3 was analysed using the sandwich enzyme-linked immunosorbent assay according to the manufacturer's instructions (The Binding Site, Birmingham, UK).Mean proMMP-3 values of the all three groups were compared and a significant statistical difference obtained (p<0.001). In addition, a statistically significant difference was found between categories of the disease and proMMP-3 values (p<0.05). The effects of age, exposure duration and cigarette smoking on proMMP-3 values in coal miners with CWP were investigated. There were no correlations between age, smoking and proMMP-3 values. However, a positive correlation was found between exposure duration and proMMP-3 values (r=0.447, p=0.008).In conclusion, proMMP-3 (prostromelysin 1) may play an essential role in degrading and remodeling the ECM in workers with pneumoconiosis. ProMMP-3 may also reflect the stage of pneumoconiosis disease.

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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