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Mediators of Inflammation
Volume 13 (2004), Issue 4, Pages 293-295
http://dx.doi.org/10.1080/09629350400003175

Induction of macrophage migration inhibitory factor precedes the onset of acute tonsillitis

1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2Department of Dermatology and Clinical Research Institute, National Tokyo Medical Center, Tokyo, Japan
3Division of Basic Research, Kitasato Institute Hospital, Tokyo, Japan
4Department of Dermatology, Kitasato Institute Hospital, Tokyo, Japan
5Department of Otolaryngology, Kitasato Institute Hospital, Tokyo, Japan
6Department of Pediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan
7Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
8Department of Pediatrics, Teine Keijinkai Hospital, Sapporo, Japan
9Department of Molecular Biochemistry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
10Department of Dermatology, Nara Medical University, 840 Shijocho, Kashihara, Nara 634-8522, Japan

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the serum macrophage migration inhibitory factor (MIF) levels of palmoplantar pustulosis patients, before and after the tonsillar provocation test. Higher serum MIF levels of palmoplantar pustulosis patients were decreased after the tonsillar provocation test (n=29). To confirm these phenomena, two patients with acute tonsillitis had their changes in body temperature, C-reactive protein (CRP) and serum MIF levels examined during the course of their illness. Surprisingly, increased MIF preceded fever and CRP elevation, and MIF subsequently decreased at the onset of fever and CRP elevation. Since MIF is an initiator of other proinflammatory cytokines, we suggest that the induction of MIF may precede other inflammatory conditions.