Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis

Voog, Ülle; Alstergren, Per; Leibur, Edvitar; Kallikorm, Riina; Kopp, Sigvard

doi:https://doi.org/10.1080/09629350400014123

Mediators of Inflammation

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Volume 13 | Article ID 874793 | https://doi.org/10.1080/09629350400014123

Influence of serotonin on the analgesic effect of granisetron on temporomandibular joint arthritis

Ülle Voog,^1,2Per Alstergren,¹Edvitar Leibur,²Riina Kallikorm,³and Sigvard Kopp¹

Abstract

THE influence of circulating serotonin (5-HT) on the effects of intra-articular administration of granisetron on temporomandibular joint (TMJ) pain was investigated in 11 patients with chronic polyarthritides. An analgesic effect superior to placebo has been shown previously.The change in TMJ movement pain intensity was negatively correlated to circulating 5-HT; that is, the higher the 5-HT before injection, the greater the reduction of pain intensity. The resting pain intensity reduction was not related to 5-HT.In conclusion, this study indicates a stronger short-term analgesic effect on TMJ movement pain by intra-articular administration of the 5-HT₃ receptor antagonist granisetron in patients with high levels of circulating 5-HT.

Copyright

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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