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Mediators of Inflammation
Volume 2005, Issue 6, Pages 390-394
http://dx.doi.org/10.1155/MI.2005.390

Effects of Antioxidant Therapy on Leukocyte Myeloperoxidase and Cu/Zn-Superoxide Dismutase and Plasma Malondialdehyde Levels in Experimental Colitis

1Department of Biochemistry, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, Turkey
2Department of Internal Medicine, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, Turkey
3Department of General Surgery, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, Turkey
4Department of Gastroenterology, Medical Faculty, Sutcu Imam University, Kahramanmaras 46050, Turkey

Received 22 June 2005; Accepted 8 August 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of the present study was to evaluate the effects of N-acetylcysteine (NAC) and L-carnitine (LCAR) supplementations on polymorphonuclear leukocytes myeloperoxidase (MPO) and Cu/Zn-superoxide dismutase (Cu/Zn-SOD) and plasma malondialdehyde (MDA) in acetic acid (AA)-induced ulcerative colitis model. The mean polymorphonuclear leukocyte MPO and Cu/Zn-SOD activity was significantly higher in the colitis group than in the control group. Both NAC and LCAR pretreatment markedly decreased MPO and Cu/Zn-SOD activity compared to colitis group. AA administration significantly increased the levels of plasma MDA in comparison with controls. However, NAC and LCAR administration to the AA-treated rats significantly reduced the MDA levels compared to colitis group. In conclusion NAC and LCAR could be beneficial agents in restoring the circulating proinflammatory mediators.