Abstract
Recent progress in the understanding of psoriasis
has shown that the regulation of local and systemic cytokines
plays an important role in its pathogenesis. The most
often used psoriasis score is the psoriasis area and severity
index (PASI). A simple laboratory test from a blood sample would
be an attractive, patient-independent, and observer-independent
marker of disease severity. To this end, we evaluated the
association of serum levels of some proinflammatory cytokines
in vivo and their correlation with severity of psoriasis.
The serum levels of cytokines levels were determined with the use
of the ELISA method. All mean values except IL-17 levels of
patients were significantly higher than those of controls. There
was a significant correlation between serum levels of IFN-