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Mediators of Inflammation
Volume 2005, Issue 3, Pages 167-170
http://dx.doi.org/10.1155/MI.2005.167

Domestic Exposure to Fungi and Total Serum IgE Levels in Asthmatic Children

1Department of Environmental and Occupational Health, Medical College, National Cheng Kung University, 138 Sheng Li Road, Tainan 70428, Taiwan
2Department of Microbiology and Immunology, Medical College, National Cheng Kung University, 138 Sheng Li Road, Tainan 70428, Taiwan
3Department of Pediatrics, Medical College, National Cheng Kung University, 138 Sheng Li Road, Tainan 70428, Taiwan

Received 9 March 2005; Accepted 21 March 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We measured the number of airborne, viable fungi and house dust mite (HDM) allergen levels in the homes of a group of asthmatic children. Blood samples were drawn and the amounts of total and specific serum IgE were determined. The association between the number of fungal colonies, dust mite allergen exposure, and specific and total IgE was evaluated. The number of viable airborne fungi was high (20 543 CFU/m) in those investigated houses. Der p1 concentrations on child's mattress exceeding 2 μg/g were found in 78.6% of the houses. A quantitative dose-response relationship was demonstrated between the exposure to viable, airborne molds and the amount of total IgE (r=0.4399 and P=.0249) and the level was further increased in children with coexposure to viable fungi and HDM.