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Mediators of Inflammation
Volume 2005, Issue 5, Pages 298-303

Repeated Doses of UVR Cause Minor Alteration in Cytokine Serum Levels in Humans

1Department of Dermatology, Medical University of Lodz, Krzemieniecka 5, Lodz 94-017, Poland
2Department of Dermatology, Basildon University Hospital, Essex, SS165NL, UK
3Laboratory of Immunochemical Research, Polish Mother's Memorial Hospital-Research Institute, Lodz 93-338, Poland
4National Public Health Institute, Bilthoven, 3720 BA, The Netherlands

Received 6 April 2005; Accepted 6 June 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of our study was to compare serum concentration of IL-1β, IL-6, IL-8, IL-10, and TNF-α in 105 healthy volunteers before and after exposure to UVR: 25 subjects (10 days of UVB), 55 (10 days of UVB or solar-simulated radiation, followed by acute UVB dose), and 25 (local high dose of UVB). In all the individuals blood samples were analyzed before and after final irradiation by chemiluminescence assay. After 10 days of UVB irradiation a statistically significant increase in serum concentration only in IL-8 (P<.05) and strong tendency in TNF-α(P=.05) were observed. The applied schedules of irradiation have minor impact on serum cytokine level and still a threshold dose of UVR causing systemic immune impairment is unknown.