Mediators of Inflammation
Volume 2005 (2005), Issue 5, Pages 293-297
http://dx.doi.org/10.1155/MI.2005.293
Vascular Endothelial Growth Factor and Placenta Growth Factor in Intrauterine Growth-Restricted Fetuses and Neonates
12nd Department of Obstetrics and Gynecology, University of Athens, Athens 11528, Greece
2Neonatal Division, 2nd Department of Obstetrics and Gynecology, University of Athens, Athens 11528, Greece
Received 17 May 2005; Accepted 21 June 2005
Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The angiogenic factors vascular endothelial growth factor (VEGF)
and placenta growth factor (PlGF) are respectively up- and
downregulated by hypoxia. We aimed to study circulating levels of
the above factors in intrauterine growth restriction (IUGR) and to
correlate their levels with the customized centiles of the
infants. The study included 25 IUGR and 25 appropriate for
gestational age (AGA) full-term, singleton infants and their
mothers. Maternal (MS), fetal (UC), and neonatal day 1 (N1) and 4
(N4) blood was examined. MS and N1 PlGF, as well as UC VEGF levels
correlated with the customized centiles of the infants (