Lars Fredriksson, Per Alstergren, Sigvard Kopp, "Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis", Mediators of Inflammation, vol. 2005, Article ID 634819, 8 pages, 2005. https://doi.org/10.1155/MI.2005.194
Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis
The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.
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