Mediators of Inflammation

Mediators of Inflammation / 2005 / Article

Open Access

Volume 2005 |Article ID 634819 |

Lars Fredriksson, Per Alstergren, Sigvard Kopp, "Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis", Mediators of Inflammation, vol. 2005, Article ID 634819, 8 pages, 2005.

Serotonergic Mechanisms Influence the Response to Glucocorticoid Treatment in TMJ Arthritis

Received09 Mar 2005
Accepted25 May 2005


The aims of this study were to investigate the influence of serotonin (5-HT) on the effects of intra-articular injections of glucocorticoid on pain of the temporomandibular joint (TMJ) in patients with inflammatory disorders of the TMJ. The pretreatment synovial fluid 5-HT was negatively, and plasma 5-HT positively, correlated to change in TMJ pain after treatment. The pretreatment plasma 5-HT was positively correlated to change in pressure-pain threshold after treatment. In conclusion, this study shows that local and systemic serotonergic mechanisms partly determine the effect of intra-articular glucocorticoid treatment on TMJ pain in patients with chronic TMJ arthritis of systemic nature, while change in pressure-pain threshold over the TMJ is influenced by systemic serotonergic mechanisms.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

More related articles

 PDF Download Citation Citation
 Order printed copiesOrder

Related articles

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.