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Mediators of Inflammation
Volume 2006, Article ID 12587, 5 pages
http://dx.doi.org/10.1155/MI/2006/12587
Research Communication

ApoE Polymorphism Is Associated With C-Reactive Protein in Low-HDL Family Members and in Normolipidemic Subjects

1Division of Cardiology, Department of Internal Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, P.O. Box 340, HUS 00029, Finland
2Baker Medical Research Institute, Melbourne, Victoria, Australia
3Department of Molecular Medicine, Biomedicum, National Public Health Institute, Helsinki 00251, Finland

Received 30 December 2005; Revised 15 March 2006; Accepted 20 March 2006

Copyright © 2006 Juhani Kahri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-selectin were measured in 211 subjects from Finnish low-HDL families and in 157 normolipidemic subjects. The subjects with apoE4 isoform had lower concentrations of serum hsCRP both in low-HDL family members (p<0.05) and in normolipidemic subjects (p<0.01). The differences in serum CRP values remained significant after adjustment for age, BMI, smoking status, hypertension, gender, lipoprotein variables, and family number. We conclude that apoE phenotype has a strong influence on serum CRP values.