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Mediators of Inflammation
Volume 2006 (2006), Article ID 13901, 4 pages
Research Communication

Plasma Levels of t-PA and PAI-1 Correlate With the Formation of Experimental Post-Surgical Peritoneal Adhesions

1Section of Pharmacology L. Donatelli, Department of Experimental Medicine, Second University of Naples, Naples 80138, Italy
2Excellence Centre for Cardiovascular Diseases, Second University of Naples, Naples 80138, Italy
3Department of Anaesthetic Sciences and Emergency Surgery, Second University of Naples, Naples 80138, Italy
4Laboratory of Hemostasis and Thrombosis, Second University of Naples, Naples 80138, Italy

Received 23 February 2006; Revised 20 April 2006; Accepted 20 April 2006

Copyright © 2006 Clara Di Filippo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study has evaluated whether systemic changes of plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) parallel the adhesions development and whether they could be used as predictors of adhesion risk. This has been studied in an animal model of post-surgical peritoneal adhesion by monitoring for 10 days the plasma and tissue levels of t-PA and PAI-1. The results showed that both tissular and plasmatic levels of t-PA were decreased in concomitance with the development of peritoneal adhesions. In contrast, PAI-1 was found increased into the tissue and into the plasma samples of the rats taken at 5 and 10 days time points. Inflammatory mediators such as ICAM-1, VCAM-1, and IL-6 within the peritoneal lavage fluid also correlated with the adhesion formation process. In conclusion, post-surgical peritoneal adhesions provide alterations of local inflammatory components and local and systemic fibrinolytic components, possibly with PAI-1 quenching t-PA. This may have potential for the identification of high-risk patients.