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Mediators of Inflammation
Volume 2006, Article ID 16492, 4 pages
http://dx.doi.org/10.1155/MI/2006/16492
Short Communication

Serum IL-18 Is Increased at Early Postburn Period in Moderately Burned Patients

1Department of Plastic Surgery, School of Medicine, Sutcu Imam University, Kahramanmaras 46100, Turkey
2Department of Microbiology and Immunology, School of Medicine, Sutcu Imam University, Kahramanmaras 46100, Turkey

Received 24 June 2005; Accepted 15 November 2005

Copyright © 2006 Y. Kenan Coban and Murat Aral. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A severe systemic inflammatory response is usually seen after burn injury. IL-18 enhances the Th1 immune responses in bacterial andviral infections. In order to evaluate the IL-18 serum levels as well as IL-6 and TNF-α at the 48th hour postburn, serial serum samples of 8 burned patients were analyzed. 8 moderately burned patients were included into the study. Serum samples were taken at admission at the 48th hour of postburn. IL-6, IL-18, and TNF-α serum levels were analyzed. Total mean burned surface area (TBSA) was 24.6±5.7% and mean BMI (body mass index) was 24.5±3.4. The patients' age ranged from 17 to 38 (mean 26.3±7.4) years. An increase in sera IL-6, IL-18, and TNF-α was detected at the 48th hour postburn (P<.0001). All patients survived. A marked increase in serum levels of IL-18 as well as the other cytokines evaluated was observed in the moderately burned patients. These three parameters were highly correlated with each other (r>0.9 and P<.001). This is the first study that shows an increase in serum IL-18 levels at the early postburn period.