Nitrooxyethylation Reverses the Healing-Suppressant Effect of Ibuprofen

Kaushal, Mandeep; Kutty, N. Gopalan; Rao, C. Mallikarjuna

doi:https://doi.org/10.1155/MI/2006/24396

Mediators of Inflammation

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Short Communication | Open Access

Volume 2006 | Article ID 024396 | https://doi.org/10.1155/MI/2006/24396

Nitrooxyethylation Reverses the Healing-Suppressant Effect of Ibuprofen

Mandeep Kaushal,¹N. Gopalan Kutty,²and C. Mallikarjuna Rao²

Received23 Jan 2006

Revised30 Mar 2006

Accepted30 Mar 2006

Published01 Jun 2006

Abstract

Nonsteroidal antiinflammatory drugs like ibuprofen impede tissue repair by virtue of retarding inflammation. The present study was undertaken to explore if linking of nitrooxyethyl ester to ibuprofen reverses its healing-depressant propensity. Nitrooxyethyl ester of ibuprofen (NOE-Ibu) was synthesized in our laboratory through a well-established synthetic pathway. NOE-Ibu was screened for its influence on collagenation, wound contraction and epithelialization phases of healing, and scar size of healed wound in three wound models, namely, incision, dead space, and excision wounds. Besides, its influence on the oxidative stress (levels of GSH and TBARS) was also determined in 10-day-old granulation tissue. NOE-Ibu was further screened for its antiinflammatory activity in rat paw edema model. NOE-Ibu promoted collagenation (increase in breaking strength, granulation weight, and collagen content), wound contraction and epithelialization phases of healing. NOE-Ibu also showed a significant antioxidant effect in 10-day-old granulation tissue as compared to ibuprofen. Results vindicate that the esterification of ibuprofen with nitrooxyethyl group reverses the healing-suppressant effect of ibuprofen. The compound also showed equipotent antiinflammatory activity as ibuprofen.

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Copyright

Copyright © 2006 Mandeep Kaushal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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