Abstract
Background. Exhaled nitric oxide (FeNO) has been
reported to be elevated in the oxidative stress involved in
asthmatic patients, and the reaction of nitric oxide (NO)
with superoxide anions results in the formation of nitrotyrosine.
The purpose of this study was to investigate the effect of inhaled
steroid treatment on nitrotyrosine levels collected by exhaled
breath condensate (EBC) and on FeNO. Methods. This
was a single-blind placebo-controlled study. The lung function,
FeNO, and nitrotyrosine levels were evaluated in 10
asthmatic children. Results. The nitrotyrosine levels
were stable during the placebo period (T0 = 1.16 ng/ml
versus T1 = 1.05 ng/ml; NS.), whereas they decreased
after the treatment with flunisolide (T2 = 1.14 ng/ml
versus T3 = 0.88 ng/ml;