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Mediators of Inflammation
Volume 2006 (2006), Article ID 32508, 5 pages
http://dx.doi.org/10.1155/MI/2006/32508
Research Communication

Soluble CD40 Ligand Levels in Otherwise Healthy Subjects With Impaired Fasting Glucose

1Department of Internal Medicine, Gulhane School of Medicine, Etlik, Ankara 06018, Turkey
2Department of Public Health, Gulhane School of Medicine, Etlik, Ankara 06018, Turkey
3Department of Biochemistry, Gulhane School of Medicine, Etlik, Ankara 06018, Turkey

Received 1 June 2006; Accepted 7 August 2006

Copyright © 2006 Ilker Tasci et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Unlike diabetes mellitus and impaired glucose tolerance, it is not clear whether the subjects with impaired fasting glucose (IFG) are at increased risk of atherosclerosis and cardiovascular diseases. The CD40-CD40 ligand interaction is involved in the mechanism of atherosclerosis. We investigated whether soluble CD40L (sCD40L) as well as high sensitive C-reactive protein (hsCRP) levels are increased in subjects with IFG having no confounding factors for inflammation or atherosclerosis. Twenty four IFG subjects with no additional disorders and 40 appropriate healthy controls were studied. sCD40L and hsCRP levels in the IFG and control groups were similar. Blood pressures, total and LDL-cholesterol, and triglyceride levels were also similar, whereas HDL-cholesterol was lower and HOMA-IR indexes were higher in the IFG group. Though the sample size was small, the present data show that sCD40L seems not to alter in subjects with IFG suggesting that it might not be an independent risk factor for atherosclerosis.