Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease

Dursun, Ahmet; Durakbasi-Dursun, Hatice Gul; Zamani, Ayse Gul; Gulbahar, Zerrin Gülin; Dursun, Recep; Yakicier, Cengiz

doi:https://doi.org/10.1155/MI/2006/41783

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 041783 | https://doi.org/10.1155/MI/2006/41783

Genetic Analysis of MEFV Gene Pyrin Domain in Patients With Behçet's Disease

Ahmet Dursun,¹Hatice Gul Durakbasi-Dursun,²Ayse Gul Zamani,²Zerrin Gülin Gulbahar,³Recep Dursun,⁴and Cengiz Yakicier³

Received03 Jan 2006

Revised20 Jan 2006

Accepted20 Jan 2006

Published20 Mar 2006

Abstract

Objectives. Behçet's disease (BD) is a systemic vasculitis with recurrent oral and genital ulcers and uveitis. MEFV gene, which is the main factor in familial Mediterranean fever (FMF), is also reported to be a susceptibility gene for BD. The pyrin domain of MEFV gene is a member of death-domain superfamily and has been proposed to regulate inflammatory signaling in myeloid cells. This study was designed to determine if mutations in pyrin domain of MEFV gene are involved in BD. Methods. We analyzed the pyrin domain of MEFV gene in 54 Turkish patients with BD by PCR-analysis and direct sequencing. Results. Neither deletion or insertion mutations nor point mutations in pyrin domain were found in any patient. Conclusion. Although pyrin gene mutations have been reported in patients with BD, pyrin domain is not mutated. However, alterations in other regions of MEFV gene and interaction between pyrin domains are needed to be further investigated.

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Copyright © 2006 Ahmet Dursun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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