Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1

Morand, Eric F.; Hall, Pam; Hutchinson, Paul; Yang, Yuan H.

doi:https://doi.org/10.1155/MI/2006/73835

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 073835 | https://doi.org/10.1155/MI/2006/73835

Regulation of Annexin I in Rheumatoid Synovial Cells by Glucocorticoids and Interleukin-1

Eric F. Morand,¹Pam Hall,¹Paul Hutchinson,¹and Yuan H. Yang¹

Received06 Jan 2006

Revised23 Jan 2006

Accepted23 Jan 2006

Published18 Mar 2006

Abstract

The glucocorticoid (GC)-induced antiinflammatory molecule annexin I is expressed in leukocytes and has antiinflammatory effects in animal models of arthritis, but the expression of annexin I in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) is unknown. We report the constitutive and dexamethasone (DEX)-inducible expression of annexin I in RA FLS. DEX increased FLS annexin I protein translocation and mRNA expression. Interleukin (IL)-1β also induced annexin I translocation and mRNA but also increased intracellular protein. DEX and IL-1 had additive effects on annexin I mRNA, but DEX inhibited the inducing effect of IL-1β on cell surface annexin I. These results indicate that glucocorticoids and IL-1β upregulate the synthesis and translocation of annexin I in RA FLS, but interdependent signalling pathways are involved.

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Copyright

Copyright © 2006 Eric F. Morand et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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