Serum Endothelin-1 and Transforming Growth Factor-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math> Levels in the Newborns With Respiratory Distress

Benzer, Derya; Aygun, A. Denizmen; Godekmerdan, Ahmet; (Citak) Kurt, A. Nese; Akarsu, Saadet; Yilmaz, Erdal

doi:https://doi.org/10.1155/MI/2006/85432

Mediators of Inflammation

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Volume 2006 | Article ID 085432 | https://doi.org/10.1155/MI/2006/85432

Serum Endothelin-1 and Transforming Growth Factor-β Levels in the Newborns With Respiratory Distress

Derya Benzer,¹A. Denizmen Aygun,¹Ahmet Godekmerdan,²A. Nese (Citak) Kurt,¹Saadet Akarsu,¹and Erdal Yilmaz¹

Received06 Mar 2006

Revised03 Jul 2006

Accepted04 Jul 2006

Published20 Sept 2006

Abstract

The purpose of this present study was to evaluate the serum levels of ET-1 and TGF-β in the newborns with respiratory distress. In this study, newborns with respiratory distress hospitalized into the Newborn Intensive Care Unit were included. The highest values of ET-1 and TGF-β were obtained from newborns with diagnosis as meconium aspiration syndrome (5.70±5.87 pg/mL and 3.75±1.94 pg/mL, resp) in the sample obtained in the first six hours after birth, and these are statistically different from control group (P<.05). Also, same results were obtained for newborns with respiratory distress syndrome (3.37±1.59 pg/mL and 2.05±0.98 pg/mL, resp). After oxygen treatment, ET-1 values obtained in the first six hours of life were decreased regularly in the following days (P<.05). In the differentiating diagnosis of the respiratory distress of newborns, the investigation of ET-1 and TGF-β levels is meaningful. The ET-1 levels investigated in the first six hours is more useful in determining the prognosis, and repeating ET-1 levels in the following days is more meaningful to determine clinical response.

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Copyright © 2006 Derya Benzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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