Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries

Malamitsi-Puchner, Ariadne; Vrachnis, Nikolaos; Samoli, Evi; Baka, Stavroula; Alexandrakis, George; Puchner, Karl-Philipp; Iliodromiti, Zoe; Hassiakos, Demetrios

doi:https://doi.org/10.1155/MI/2006/94381

Mediators of Inflammation

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Research Communication | Open Access

Volume 2006 | Article ID 094381 | https://doi.org/10.1155/MI/2006/94381

Investigation of Midtrimester Amniotic Fluid Factors as Potential Predictors of Term and Preterm Deliveries

Ariadne Malamitsi-Puchner,¹Nikolaos Vrachnis,¹Evi Samoli,¹Stavroula Baka,¹George Alexandrakis,¹Karl-Philipp Puchner,¹Zoe Iliodromiti,¹and Demetrios Hassiakos¹

Received15 Feb 2006

Revised28 Mar 2006

Accepted29 Mar 2006

Published07 May 2006

Abstract

Aims. Our aim is to investigate, in 13 cases (delivering preterm) and 21 matched (for age, parity, and gestational age) controls (delivering at term), whether midtrimester amniotic fluid concentrations of elastase, secretory leukocyte proteinase inhibitor (SLPI), soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule predict asymptomatic intra-amniotic inflammation/infection and preterm labor. Results. Concentrations of all substances were not statistically different among mothers, delivering preterm or at term. SLPI concentrations significantly increased in women, going into labor without ruptured membranes, irrespective of pre- or term delivery (P<.007, P<.001, resp) and correlated with elastase (r=0.508, P<.002). Conclusions. Midtrimester amniotic fluid SLPI concentrations significantly decrease when membrane rupture precedes pre- or full-term labor. However, none of the investigated substances predict preterm delivery.

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Copyright © 2006 Ariadne Malamitsi-Puchner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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