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Mediators of Inflammation
Volume 2006, Article ID 97257, 5 pages
Short Communication

Similar Effects of General and Spinal Anaesthesia on Perioperative Stress Response in Patients Undergoing Haemorrhoidectomy

1Department of Anaesthesiology and Reanimation, School of Medicine, Kirikkale University, Kirikkale 71100, Turkey
2Kuyuyazisi Caddesi 23/9, Etlik, Ankara 06010, Turkey
3Department of Biochemistry, School of Medicine, Kirikkale University, Kirikkale 71100, Turkey
4Department of General Surgery, School of Medicine, Kirikkale University, Turkey 71100, Turkey

Received 22 July 2005; Accepted 21 October 2005

Copyright © 2006 Unase Buyukkocak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-α: TNF-α), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n=7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-α, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-α and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.