Mediators of Inflammation

Mediators of Inflammation / 2007 / Article

Clinical Study | Open Access

Volume 2007 |Article ID 019564 | https://doi.org/10.1155/2007/19564

Chelbi Hanene, Lachheb Jihene, Ammar Jamel, Hamzaoui Kamel, Hamzaoui Agnès, "Association of GST Genes Polymorphisms with Asthma in Tunisian Children", Mediators of Inflammation, vol. 2007, Article ID 019564, 6 pages, 2007. https://doi.org/10.1155/2007/19564

Association of GST Genes Polymorphisms with Asthma in Tunisian Children

Received08 Nov 2006
Revised26 Jan 2007
Accepted27 Jan 2007
Published19 Mar 2007

Abstract

Background. A positive association between genetic polymorphism and asthma may not be extrapolated from one ethnic group to another based on intra- and interethnic allelic and genotype frequencies differences. Objective. We assessed whether polymorphisms of GST genes (GSTM1, GSTT1, and GSTP1) are associated with asthma and atopy among Tunisian children. Methods. 112 unrelated healthy individuals and 105 asthmatic (73 atopic and 32 nonatopic) children were studied. Genotyping the polymorphisms in the GSTT1 and GSTM1 genes was performed using the multiplex PCR. The GSTP1 ILe105Val polymorphism was determined using PCR-RFLP. Results. GSTM1 null genotype was significantly associated with the increased risk of asthma (P=.002). Asthmatic children had a higher prevalence of the GSTP1Ile105 allele than the control group (43.8% and 33.5%, respectively; P=.002). Also, the presence of the GSTP1 homozygote Val/Val was less common in subjects with asthma than in control group. We have found that GSTT1 null genotype (GSTT10/0) was significantly associated with atopy (P=.008). Conclusion. Polymorphisms within genes of the GST superfamily were associated with risk of asthma and atopy in Tunisia.

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Copyright © 2007 Chelbi Hanene et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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