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Mediators of Inflammation
Volume 2007 (2007), Article ID 19854, 5 pages
http://dx.doi.org/10.1155/2007/19854
Clinical Study

Th1/Th2 Cytokine Ratio in Tissue Transudates from Patients with Oral Lichen Planus

1Division of Oral Medicine and Diagnosis, Department of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA
2Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou 510060, China
3Department of Otolaryngology, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA

Received 12 September 2006; Revised 17 December 2006; Accepted 17 December 2006

Copyright © 2007 Nelson L. Rhodus et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Rengarajan, S. J. Szabo, and L. H. Glimcher, “Transcriptional regulation of Th1/Th2 polarization,” Immunology Today, vol. 21, no. 10, pp. 479–483, 2000. View at Publisher · View at Google Scholar
  2. D. O. Gor, N. R. Rose, and N. S. Greenspan, “TH1TH2: a procrustean paradigm,” Nature Immunology, vol. 4, no. 6, pp. 503–505, 2003. View at Publisher · View at Google Scholar
  3. K. Hamzaoui, A. Hamzaoui, F. Guemira, M. Bessioud, M. Hamza, and K. Ayed, “Cytokine profile in Behçet's disease patients: relationship with disease activity,” Scandinavian Journal of Rheumatology, vol. 31, no. 4, pp. 205–210, 2002. View at Publisher · View at Google Scholar
  4. M. Ramos-Casals, M. García-Carrasco, R. Cervera et al., “Th1/Th2 cytokine imbalance in patients with Sjögren syndrome secondary to hepatitis C virus infection,” Seminars in Arthritis and Rheumatism, vol. 32, no. 1, pp. 56–63, 2002. View at Publisher · View at Google Scholar
  5. K. Ghoreschi, U. Mrowietz, and M. Röcken, “A molecule solves psoriasis? Systemic therapies for psoriasis inducing interleukin 4 and Th2 responses,” Journal of Molecular Medicine, vol. 81, no. 8, pp. 471–480, 2003. View at Publisher · View at Google Scholar
  6. K. Ghoreschi, P. Thomas, S. Breit et al., “Interleukin-4 therapy of psoriasis induces Th2 responses and improves human autoimmune disease,” Nature Medicine, vol. 9, no. 1, pp. 40–46, 2003. View at Publisher · View at Google Scholar
  7. D. Pohlers, K. Nissler, O. Frey et al., “Anti-CD4 monoclonal antibody treatment in acute and early chronic antigen-induced arthritis: influence on T helper cell activation,” Clinical and Experimental Immunology, vol. 135, no. 3, pp. 409–415, 2004. View at Publisher · View at Google Scholar
  8. H.-U. Simon, H. Seelbach, R. Ehmann, and M. Schmitz, “Clinical and immunological effects of low-dose IFN-α treatment in patients with corticosteroid-resistant asthma,” Allergy, vol. 58, no. 12, pp. 1250–1255, 2003. View at Publisher · View at Google Scholar
  9. C. Simark-Mattsson, G. Bergenholtz, M. Jontell et al., “Distribution of interleukin-2, -4, -10, tumour necrosis factor-a and transforming growth factor-ß mRNAs in oral lichen planus,” Archives of Oral Biology, vol. 44, no. 6, pp. 499–507, 1999. View at Publisher · View at Google Scholar
  10. F. Chiappelli, M. A. Kung, P. Nguyen, P. Villanueva, E. A. Farhadian, and L. R. Eversole, “Cellular immune correlates of clinical severity in oral lichen planus: preliminary association with mood states,” Oral Diseases, vol. 3, no. 2, pp. 64–70, 1997. View at Google Scholar
  11. E. E. Karagouni, E. N. Dotsika, and A. Sklavounou, “Alteration in peripheral blood mononuclear cell function and serum cytokines in oral lichen planus,” Journal of Oral Pathology and Medicine, vol. 23, no. 1, pp. 28–35, 1994. View at Publisher · View at Google Scholar
  12. A. Khan, C. S. Farah, N. W. Savage, L. J. Walsh, D. J. Harbrow, and P. B. Sugerman, “Th1 cytokines in oral lichen planus,” Journal of Oral Pathology and Medicine, vol. 32, no. 2, pp. 77–83, 2003. View at Publisher · View at Google Scholar
  13. A. Fayyazi, S. Schweyer, A. Soruri et al., “T lymphocytes and altered keratinocytes express interferon-? and interleukin 6 in lichen planus,” Archives of Dermatological Research, vol. 291, no. 9, pp. 485–490, 1999. View at Publisher · View at Google Scholar
  14. C. Simark-Mattsson, M. Jontell, G. Bergenholtz, M. Heyden, and U. I. Dahlgren, “Distribution of interferon-γ mRNA-positive cells in oral lichen planus lesions,” Journal of Oral Pathology and Medicine, vol. 27, no. 10, pp. 483–488, 1998. View at Google Scholar
  15. S. Pezelj-Ribaric, I. B. Prso, M. Abram, I. Glazar, G. Brumini, and M. Simunovic-Soskic, “Salivary levels of tumor necrosis factor-α in oral lichen planus,” Mediators of Inflammation, vol. 13, no. 2, pp. 131–133, 2004. View at Publisher · View at Google Scholar
  16. A. Sklavounou, E. Chrysomali, A. Scorilas, and A. Karameris, “TNF-α expression and apoptosis-regulating proteins in oral lichen planus: a comparative immunohistochemical evaluation,” Journal of Oral Pathology and Medicine, vol. 29, no. 8, pp. 370–375, 2000. View at Publisher · View at Google Scholar
  17. T. Yamamoto, T. Osaki, K. Yoneda, and E. Ueta, “Cytokine production by keratinocytes and mononuclear infiltrates in oral lichen planus,” Journal of Oral Pathology and Medicine, vol. 23, no. 7, pp. 309–315, 1994. View at Publisher · View at Google Scholar
  18. T. Yamamoto and T. Osaki, “Characteristic cytokines generated by keratinocytes and mononuclear infiltrates in oral lichen planus,” Journal of Investigative Dermatology, vol. 104, no. 5, pp. 784–788, 1995. View at Publisher · View at Google Scholar
  19. A. Sun, J.-S. Chia, Y.-F. Chang, and C.-P. Chiang, “Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus,” Journal of Oral Pathology and Medicine, vol. 31, no. 4, pp. 196–203, 2002. View at Publisher · View at Google Scholar
  20. A. Karatsaidis, O. Schreurs, T. Axéll, K. Helgeland, and K. Schenck, “Inhibition of the transforming growth factor-β/Smad signaling pathway in the epithelium of oral lichen,” Journal of Investigative Dermatology, vol. 121, no. 6, pp. 1283–1290, 2003. View at Publisher · View at Google Scholar
  21. M. Zehnder, J. S. Greenspan, D. Greenspan, and M. Bickel, “Chemokine gene expression in human oral mucosa,” European Journal of Oral Sciences, vol. 107, no. 4, pp. 231–235, 1999. View at Publisher · View at Google Scholar
  22. M. C. Little, C. E. M. Griffiths, R. E. B. Watson, M. N. Pemberton, and M. H. Thornhill, “Oral mucosal keratinocytes express RANTES and ICAM-1, but not interleukin-8, in oral lichen planus and oral lichenoid reactions induced by amalgam fillings,” Clinical and Experimental Dermatology, vol. 28, no. 1, pp. 64–69, 2003. View at Publisher · View at Google Scholar
  23. P. B. Sugerman, N. W. Savage, L. J. Walsh et al., “The pathogenesis of oral lichen planus,” Critical Reviews in Oral Biology and Medicine, vol. 13, no. 4, pp. 350–365, 2002. View at Google Scholar
  24. J. W. Little, D. A. Falace, C. S. Miller, and N. L. Rhodus, Eds., Dental Management of the Medically Compromised Patient, Mosby, Saint Louis, Mo, USA, 6th edition, 2002.
  25. N. L. Rhodus, L. Dahmer, K. Lindemann, J. Rudney, A. Mathur, and J. Bereuter, “s-IgA and cytokine levels in whole saliva of Sjögren's syndrome patients before and after oral pilocarpine hydrochloride administration: a pilot study,” Clinical Oral Investigations, vol. 2, no. 4, pp. 191–196, 1998. View at Publisher · View at Google Scholar
  26. F. Ondrey, G. Dong, J. Sunwoo et al., “Constitutive activation of transcription factors NF-?B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines,” Molecular Carcinogenesis, vol. 26, no. 2, pp. 119–129, 1999. View at Publisher · View at Google Scholar
  27. I. Krause, G. Valesini, R. Scrivo, and Y. Shoenfeld, “Autoimmune aspects of cytokine and anticytokine therapies,” American Journal of Medicine, vol. 115, no. 5, pp. 390–397, 2003. View at Publisher · View at Google Scholar
  28. M. Voulgarelis, S. Giannouli, D. Anagnostou, and A. G. Tzioufas, “Combined therapy with rituximab plus cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) for Sjögren's syndrome-associated B-cell aggressive non-Hodgkin's lymphomas,” Rheumatology, vol. 43, no. 8, pp. 1050–1053, 2004. View at Publisher · View at Google Scholar
  29. M. M. Zandbelt, P. C. M. de Wilde, P. A. van Damme, C. B. Hoyng, L. B. A. van de Putte, and F. H. J. van den Hoogen, “Etanercept in the treatment of patients with primary Sjögren's syndrome: a pilot study,” Journal of Rheumatology, vol. 31, no. 1, pp. 96–101, 2004. View at Google Scholar
  30. S. Diehl and M. Rincón, “The two faces of IL-6 on Th1/Th2 differentiation,” Molecular Immunology, vol. 39, no. 9, pp. 531–536, 2002. View at Publisher · View at Google Scholar
  31. S. Babu and T. B. Nutman, “Proinflammatory cytokines dominate the early immune response to filarial parasites,” Journal of Immunology, vol. 171, no. 12, pp. 6723–6732, 2003. View at Google Scholar
  32. T. Yamamoto, K. Yoneda, E. Ueta, and T. Osaki, “Serum cytokines, interleukin-2 receptor, and soluble intercellular adhesion molecule-1 in oral disorders,” Oral Surgery, Oral Medicine, Oral Pathology, vol. 78, no. 6, pp. 727–735, 1994. View at Publisher · View at Google Scholar
  33. U. Costabel and J. Guzman, “Bronchoalveolar lavage in interstitial lung disease,” Current Opinion in Pulmonary Medicine, vol. 7, no. 5, pp. 255–261, 2001. View at Publisher · View at Google Scholar
  34. L. Liu, N. N. Jarjour, W. W. Busse, and E. A. B. Kelly, “Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma,” American Journal of Respiratory and Critical Care Medicine, vol. 169, no. 10, pp. 1118–1124, 2004. View at Publisher · View at Google Scholar
  35. F. Saint, N. Kurth, P. Maille et al., “Urinary IL-2 assay for monitoring intravesical bacillus Calmette-Guérin response of superficial bladder cancer during induction course and maintenance therapy,” International Journal of Cancer, vol. 107, no. 3, pp. 434–440, 2003. View at Publisher · View at Google Scholar
  36. S.-H. Park, D.-J. Min, M.-L. Cho et al., “Shift toward T helper 1 cytokines by type II collagen-reactive T cells in patients with rheumatoid arthritis,” Arthritis and Rheumatism, vol. 44, no. 3, pp. 561–569, 2001. View at Publisher · View at Google Scholar
  37. K. Kaneyama, N. Segami, J. Sato, M. Nishimura, and H. Yoshimura, “Interleukin-6 family of cytokines as biochemical markers of osseous changes in the temporomandibular joint disorders,” British Journal of Oral and Maxillofacial Surgery, vol. 42, no. 3, pp. 246–250, 2004. View at Publisher · View at Google Scholar
  38. P. Sfriso, P. A. Ostuni, C. Botsios et al., “Serum and salivary neopterin and interferon-? in primary Sjögren's syndrome: correlation with clinical, laboratory and histopathologic features,” Scandinavian Journal of Rheumatology, vol. 32, no. 2, pp. 74–78, 2003. View at Publisher · View at Google Scholar
  39. S. Ruhl, S. Homberaer, R. Betz et al., “Salivary proteins and cytokines in drug-induced gingival overgrowth,” Journal of Dental Research, vol. 83, no. 4, pp. 322–326, 2004. View at Google Scholar