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Mediators of Inflammation
Volume 2007, Article ID 31397, 5 pages
http://dx.doi.org/10.1155/2007/31397
Research Article

Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis

1Department of Pediatrics, Faculty of Medicine, Firat University, Elazig 23119, Turkey
2Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119, Turkey

Received 10 May 2007; Accepted 31 October 2007

Copyright © 2007 A. Nese Citak Kurt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. Volante, S. Moretti, F. Pisani, and G. Bevilacqua, “Early diagnosis of bacterial infection in the neonate,” Journal of Maternal-Fetal & Neonatal Medicine, vol. 16, supplement 2, pp. 13–16, 2004. View at Publisher · View at Google Scholar · View at PubMed
  2. I. M. Gladstone, R. A. Ehrenkranz, S. C. Edberg, and R. S. Baltimore, “A ten-year review of neonatal sepsis and comparison with the previous fifty-year experience,” Pediatric Infectious Disease Journal, vol. 9, no. 11, pp. 819–825, 1990.
  3. R. Vesikari, M. Janas, and P. Grönroos et al., “Neonatal septicaemia,” Archives of Disease in Childhood, vol. 60, no. 6, pp. 542–546, 1985.
  4. P. Kite, M. R. Millar, P. Gorham, and P. Congdon, “Comparison of five tests used in diagnosis of neonatal bacteraemia,” Archives of Disease in Childhood, vol. 63, no. 6, pp. 639–643, 1988.
  5. E. Ainbender, E. E. Cabatu, D. M. Guzman, and A. Y. Sweet, “Serum C-reactive protein and problems of newborn infants,” Journal of Pediatrics, vol. 101, no. 3, pp. 438–440, 1982. View at Publisher · View at Google Scholar
  6. O. Da Silva, A. Ohlsson, and C. Kenyon, “Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review,” Pediatric Infectious Disease Journal, vol. 14, no. 5, pp. 1119–1120, 1995.
  7. B. L. Manroe, A. G. Weinberg, C. R. Rosenfeld, and R. Browne, “The neonatal blood count in health and disease. I. Reference values for neutrophilic cells,” Journal of Pediatrics, vol. 95, no. 1, pp. 89–98, 1979. View at Publisher · View at Google Scholar
  8. A. Zipursky, J. Palko, R. Milner, and G. I. Akenzua, “The hematology of bacterial infections in premature infants,” Pediatrics, vol. 57, no. 6, pp. 839–853, 1976.
  9. N. J. Mathers and F. Pohlandt, “Diagnostic audit of C-reactive protein in neonatal infection,” European Journal of Pediatrics, vol. 146, no. 2, pp. 147–151, 1987. View at Publisher · View at Google Scholar
  10. L. Sann, F. Bienvenu, and J. Bienvenu, “Evolution of serum prealbumin, C-reactive protein, and orosomucoid in neonates with bacterial infection,” Journal of Pediatrics, vol. 105, no. 6, pp. 977–981, 1984. View at Publisher · View at Google Scholar
  11. R. Berner, C. M. Niemeyer, and J. U. Leititis et al., “Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis,” Pediatric Research, vol. 44, no. 4, pp. 469–477, 1998. View at Publisher · View at Google Scholar
  12. M. S. Cairo, “Neonatal neutrophil host defense. Prospects for immunologic enhancement during neonatal sepsis,” American Journal of Diseases of Children, vol. 143, no. 1, pp. 40–46, 1989.
  13. C. Buck, J. Bundschu, H. Gallati, P. Bartmann, and F. Pohlandt, “Interleukin-6: a sensitive parameter for the early diagnosis of neonatal bacterial infection,” Pediatrics, vol. 93, no. 1, pp. 54–58, 1994.
  14. E. S. de Bont, A. Martens, and J. van Raan et al., “Diagnostic value of plasma levels of tumor necrosis factor α (TNFα) and interleukin-6 (IL-6) in newborns with sepsis,” Acta Paediatrica, vol. 83, no. 7, pp. 696–699, 1994.
  15. M. C. Harris, A. T. Costarino Jr., and J. S. Sullivan et al., “Cytokine elevations in critically ill infants with sepsis and necrotizing enterocolitis,” Journal of Pediatrics, vol. 124, no. 1, pp. 105–111, 1994. View at Publisher · View at Google Scholar
  16. T. Matthes, C. Werner-Favre, H. Tang, X. Zhang, V. Kindler, and R. H. Zubler, “Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor α, interleukin (IL)6, IL-10, and transforming growth factor β1 mRNAs,” Journal of Experimental Medicine, vol. 178, no. 2, pp. 521–528, 1993. View at Publisher · View at Google Scholar
  17. H. Martin, B. Olander, and M. Norman, “Reactive hyperemia and interleukin 6, interleukin 8, and tumor necrosis factor-α in the diagnosis of early-onset neonatal sepsis,” Pediatrics, vol. 108, no. 4, pp. 1–6, 2001. View at Publisher · View at Google Scholar
  18. A. G. Philip and J. R. Hewitt, “Early diagnosis of neonatal sepsis,” Pediatrics, vol. 65, no. 5, pp. 1036–1041, 1980.
  19. G. I. Akenzua, Y. T. Hui, R. Milner, and A. Zipursky, “Neutrophil and band counts in the diagnosis of neonatal infections,” Pediatrics, vol. 54, no. 1, pp. 38–42, 1974.
  20. M. Xanthou, “Leukocyte blood picture in ill newborn babies,” Archives of Disease in Childhood, vol. 47, no. 255, pp. 741–743, 1972.
  21. V. Manucha, U. Rusia, M. Sikka, M. M. A. Faridi, and N. Madan, “Utility of haematological parameters and C-reactive protein in the detection of neonatal sepsis,” Journal of Paediatrics and Child Health, vol. 38, no. 5, pp. 459–464, 2002. View at Publisher · View at Google Scholar
  22. P. W. Fowlie and B. Schmidt, “Diagnostic tests for bacterial infection from birth to 90 days—a systematic review,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 78, no. 2, pp. F92–F98, 1998.
  23. O. Da Silva, A. Ohlsson, and C. Kenyon, “Accuracy of leukocyte indices and C-reactive protein for diagnosis of neonatal sepsis: a critical review,” Pediatric Infectious Disease Journal, vol. 14, no. 5, pp. 362–366, 1995.
  24. X. Saez-Llorens and S. F. Lagrutta, “The acute phase host reaction during bacterial infection and its clinical impact in children,” Pediatric Infectious Disease Journal, vol. 12, no. 1, pp. 83–87, 1993.
  25. E. S. de Bont, A. Martens, and J. van Raan et al., “Tumor necrosis factor-α, interleukin-1β, and interleukin-6 plasma levels in neonatal sepsis,” Pediatric Research, vol. 33, no. 4, part 1, pp. 380–383, 1993.
  26. A. Ozdemir, N. Oygur, M. Gultekin, M. Coskun, and O. Yegin, “Neonatal tumor necrosis factor, interleukin-1α, interleukin-1β, and interleukin-6 response to infection,” American Journal of Perinatology, vol. 11, no. 4, pp. 282–285, 1994.
  27. P. C. Ng, S. H. Cheng, and K. M. Chui et al., “Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low birthweight infants,” Archives of Disease in Childhood: Fetal and Neonatal Edition, vol. 77, no. 3, pp. F221–F227, 1997.
  28. C. Santana Reyes, F. García-Muñoz, D. Reyes, G. González, C. Dominguez, and E. Domenech, “Role of cytokines (interleukin-1β, 6, 8, tumour necrosis factor-α, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis,” Acta Paediatrica, vol. 92, no. 2, pp. 221–227, 2003.
  29. L. C. Miller, S. Isa, G. LoPreste, J. G. Schaller, and C. A. Dinarello, “Neonatal interleukin-1β-, interleukin-6, and tumor necrosis factor: cord blood levels and cellular production,” Journal of Pediatrics, vol. 117, no. 6, pp. 961–965, 1990. View at Publisher · View at Google Scholar
  30. J. D. M. Edgar, D. C. Wilson, and S. A. McMillan et al., “Predictive value of soluble immunological mediators in neonatal infection,” Clinical Science, vol. 87, no. 2, pp. 165–171, 1994.
  31. M. Kantar, N. Kültürsay, N. Kütükçüler, M. Akisü, N. Çetingül, and S. Çaglayan, “Plasma concentrations of granulocyte-macrophage colony-stimulating factor and interleukin-6 in septic and healthy preterms,” European Journal of Pediatrics, vol. 159, no. 3, pp. 156–157, 2000. View at Publisher · View at Google Scholar
  32. O. Magudumana, D. E. Ballot, and P. A. Cooper et al., “Serial interleukin 6 measurements in the early diagnosis of neonatal sepsis,” Journal of Tropical Pediatrics, vol. 46, no. 5, pp. 267–271, 2000. View at Publisher · View at Google Scholar
  33. T. Lehrnbecher, L. Schrod, D. Kraus, T. Roos, J. Martius, and H.-B. von Stockhausen, “Interleukin-6 and soluble interleukin-6 receptor in cord blood in the diagnosis of early onset sepsis in neonates,” Acta Paediatrica, vol. 84, no. 7, pp. 806–808, 1995.
  34. M. C. Harris, A. T. Costarino Jr., and J. S. Sullivan et al., “Cytokine elevations in critically ill infants with sepsis and necrotizing enterocolitis,” Journal of Pediatrics, vol. 124, no. 1, pp. 105–111, 1994. View at Publisher · View at Google Scholar
  35. A. R. Franz, G. Steinbach, M. Kron, and F. Pohlandt, “Reduction of unnecessary antibiotic therapy in newborn infants using interleukin-8 and C-reactive protein as markers of bacterial infections,” Pediatrics, vol. 104, no. 3, pp. 447–453, 1999. View at Publisher · View at Google Scholar
  36. A. R. Franz, G. Steinbach, M. Kron, and F. Pohlandt, “Interleukin-8: a valuable tool to restrict antibiotic therapy in newborn infants,” Acta Paediatrica, vol. 90, no. 9, pp. 1025–1032, 2001. View at Publisher · View at Google Scholar
  37. E. Kocabaş, A. Sarikçioǧlu, N. Aksaray, G. Seydaoǧlu, Y. Seyhun, and A. Yaman, “Role of procalcitonin, C-reactive protein, interleukin-6, interleukin-8 and tumor necrosis factor-α in the diagnosis of neonatal sepsis,” Turkish Journal of Pediatrics, vol. 49, no. 1, pp. 7–20, 2007.
  38. J. Messer, D. Eyer, L. Donato, H. Gallati, J. Martis, and U. Simeoni, “Evaluation of interleukin-6 and soluble receptors of tumor necrosis factor for early diagnosis of neonatal infection,” Journal of Pediatrics, vol. 129, no. 4, pp. 574–580, 1996. View at Publisher · View at Google Scholar
  39. M. Oberhoffer, H. Vogelsang, S. Rußwurm, T. Hartung, and K. Reinhart, “Outcome prediction by traditional and new markers of inflammation in patients with sepsis,” Clinical Chemistry and Laboratory Medicine, vol. 37, no. 3, pp. 363–368, 1999. View at Publisher · View at Google Scholar