Serum Leptin Levels in Patients with Ocular and 
Nonocular Behçet's Disease

Yalçındağ, F. Nilüfer; Kısa, Üçler; Batıoğlu, Figen; Yalçındağ, Ali; Özdemir, Özden; Çağlayan, Osman

doi:https://doi.org/10.1155/2007/31986

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 031986 | https://doi.org/10.1155/2007/31986

Serum Leptin Levels in Patients with Ocular and Nonocular Behçet's Disease

F. Nilüfer Yalçındağ,¹Üçler Kısa,²Figen Batıoğlu,¹Ali Yalçındağ,²Özden Özdemir,¹and Osman Çağlayan²

Received09 Feb 2007

Accepted13 Mar 2007

Published14 May 2007

Abstract

Aims. To investigate serum leptin levels in Behçet's patients with or without ocular involvement compared with healthy subjects and the relationship between serum leptin and uveitis activity in patients with ocular involvement. Methods. Fifty-seven patients with Behçet's disease and 20 healthy control subjects were included in this study. While 27 patients had ocular involvement (18 had acute uveitis, 9 had inactive ocular involvement), 30 did not have ocular disease. C-reactive protein, alpha 1-antitrypsin, and serum leptin levels were measured in all samples. Results. There was a significant difference between the patients with Behçet's disease and control group for both logarithm of leptin (P=.000) and logarithm of CRP (P=.031). Logarithm of leptin in non-ocular Behçet's patients was significantly higher compared to its level in ocular Behçet's disease and controls (P=.009). There was a significant difference between the patients with active ocular disease and control group (P=.03). Conclusions. Leptin might have a possible role in the pathogenesis of Behçet's disease.

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Copyright

Copyright © 2007 F. Nilüfer Yalçındağ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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