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Mediators of Inflammation
Volume 2007 (2007), Article ID 31986, 4 pages
http://dx.doi.org/10.1155/2007/31986
Clinical Study

Serum Leptin Levels in Patients with Ocular and Nonocular Behçet's Disease

1Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara 06100, Turkey
2Department of Clinical Biochemistry, Faculty of Medicine, Kırıkkale University, Kırıkkale 71200, Turkey

Received 9 February 2007; Accepted 13 March 2007

Copyright © 2007 F. Nilüfer Yalçındağ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. To investigate serum leptin levels in Behçet's patients with or without ocular involvement compared with healthy subjects and the relationship between serum leptin and uveitis activity in patients with ocular involvement. Methods. Fifty-seven patients with Behçet's disease and 20 healthy control subjects were included in this study. While 27 patients had ocular involvement (18 had acute uveitis, 9 had inactive ocular involvement), 30 did not have ocular disease. C-reactive protein, alpha 1-antitrypsin, and serum leptin levels were measured in all samples. Results. There was a significant difference between the patients with Behçet's disease and control group for both logarithm of leptin (P=.000) and logarithm of CRP (P=.031). Logarithm of leptin in non-ocular Behçet's patients was significantly higher compared to its level in ocular Behçet's disease and controls (P=.009). There was a significant difference between the patients with active ocular disease and control group (P=.03). Conclusions. Leptin might have a possible role in the pathogenesis of Behçet's disease.