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Mediators of Inflammation
Volume 2007 (2007), Article ID 38210, 4 pages
http://dx.doi.org/10.1155/2007/38210
Research Article

Tumor Necrosis Factor-Alpha and Interleukin 6 in Human Periapical Lesions

1Department of Dentistry, Medical Faculty, University of Rijeka, Rijeka HR 51000, Croatia
2Department of Histology, Medical Faculty, University of Rijeka, Rijeka HR 51000, Croatia
3Department of Informatics, Medical Faculty, University of Rijeka, Rijeka HR 51000, Croatia
4School of Dental Medicine, University of Zagreb, Zagreb HR 10000, Croatia

Received 24 August 2006; Revised 6 November 2006; Accepted 8 November 2006

Copyright © 2007 Ivana Brekalo Pršo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in human periapical lesions. Subjects and methods. Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a control. Results. TNF-alpha levels were significantly increased in symptomatic lesions compared to control. Group with asymptomatic lesions had significantly higher concentrations compared to control. There were no significant differences in TNF-alpha levels between symptomatic and asymptomatic lesions. In group with symptomatic lesions, IL-6 levels were significantly higher than in group with asymptomatic lesions. The IL-6 levels in symptomatic group also showed significantly higher concentration in comparison with control group. In asymptomatic group, the IL-6 level had significantly higher concentrations compared to control. Conclusion. These results indicate that symptomatic lesions represent an immunologically active stage of disease, and asymptomatic lesions are the point from which the process advances toward healing.