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Mediators of Inflammation
Volume 2007, Article ID 42646, 6 pages
Clinical Study

Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs

1Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, Greece
2Research Laboratories, Second Department of Pediatrics, Athens University Medical School, Athens 11527, Greece

Received 17 October 2006; Revised 4 January 2007; Accepted 30 January 2007

Copyright © 2007 Ariadne Malamitsi-Puchner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased in AGA (P<.001 and P=.037, resp.). N1 insulin levels were lower in IUGR (P=.048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with customized centiles (r=.374, P=.035, r=.608, P<.001, r=.485, P=.006, and r=.654, P=.021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P=.023 and P=.016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal insulin levels with customized centiles underline implication of both hormones in fetal growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in females.