Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and 
      Growth-Restricted Mother/Infant Pairs

Malamitsi-Puchner, Ariadne; Briana, Despina D.; Gourgiotis, Dimitrios; Boutsikou, Maria; Puchner, Karl-Philipp; Baka, Stavroula; Marmarinos, Antonios; Hassiakos, Dimitrios

doi:https://doi.org/10.1155/2007/42646

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 042646 | https://doi.org/10.1155/2007/42646

Insulin-Like Growth Factor (IGF)-I and Insulin in Normal and Growth-Restricted Mother/Infant Pairs

Ariadne Malamitsi-Puchner,¹Despina D. Briana,¹Dimitrios Gourgiotis,²Maria Boutsikou,¹Karl-Philipp Puchner,¹Stavroula Baka,¹Antonios Marmarinos,²and Dimitrios Hassiakos¹

Received17 Oct 2006

Revised04 Jan 2007

Accepted30 Jan 2007

Published13 Mar 2007

Abstract

Insulin-like growth factor (IGF)-I and insulin are essential for fetal growth. We investigated perinatal changes of both factors in 40 mothers and their 20 appropriate-for-gestational-age (AGA) and 20 intrauterine-growth-restricted (IUGR) fetuses and neonates on day 1 (N1) and day 4 (N4) postpartum. Fetal and N1, but not N4, IGF-I levels were increased in AGA (P<.001 and P=.037, resp.). N1 insulin levels were lower in IUGR (P=.048). Maternal, fetal, and N1 IGF-I, and fetal insulin levels positively correlated with customized centiles (r=.374, P=.035, r=.608, P<.001, r=.485, P=.006, and r=.654, P=.021, resp.). Female infants presented elevated fetal and N4 IGF-I levels (P=.023 and P=.016, resp.). Positive correlations of maternal, fetal, and neonatal IGF-I levels, and fetal insulin levels with customized centiles underline implication of both hormones in fetal growth. IUGR infants present gradually increasing IGF-I levels. Higher IGF-I levels are documented in females.

References

R. Randhawa and P. Cohen, “The role of the insulin-like growth factor system in prenatal growth,” Molecular Genetics and Metabolism, vol. 86, no. 1-2, pp. 84–90, 2005.
View at: Publisher Site | Google Scholar
D. J. P. Barker, P. D. Gluckman, K. M. Godfrey, J. E. Harding, J. A. Owens, and J. S. Robinson, “Fetal nutrition and cardiovascular disease in adult life,” Lancet, vol. 341, no. 8850, pp. 938–941, 1993.
View at: Publisher Site | Google Scholar
P. D. Gluckman and J. E. Harding, “Fetal growth retardation: underlying endocrine mechanisms and postnatal consequences,” Acta Paediatrica, vol. 86, no. 422, pp. 69–72, 1997.
View at: Google Scholar
M. S. Boyne, M. Thame, F. I. Bennett, C. Osmond, J. P. Miell, and T. E. Forrester, “The relationship among circulating insulin-like growth factor (IGF)-I, IGF-binding proteins-1 and -2, and birth anthropometry: a prospective study,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, pp. 1687–1691, 2003.
View at: Publisher Site | Google Scholar
V. R. Sara and K. Hall, “Insulin-like growth factors and their binding proteins,” Physiological Reviews, vol. 70, no. 3, pp. 591–614, 1990.
View at: Google Scholar
I. Turkalj, U. Keller, R. Ninnis, S. Vosmeer, and W. Stauffacher, “Effect of increasing doses of recombinant human insulin-like growth factor-I on glucose, lipid, and leucine metabolism in man,” Journal of Clinical Endocrinology and Metabolism, vol. 75, no. 5, pp. 1186–1191, 1992.
View at: Publisher Site | Google Scholar
J. Baker, J.-P. Liu, E. J. Robertson, and A. Efstratiadis, “Role of insulin-like growth factors in embryonic and postnatal growth,” Cell, vol. 75, no. 1, pp. 73–82, 1993.
View at: Publisher Site | Google Scholar
A. L. Fowden, “The insulin-like growth factors and feto-placental growth,” Placenta, vol. 24, no. 8-9, pp. 803–812, 2003.
View at: Publisher Site | Google Scholar
A. L. Fowden, “The role of insulin in prenatal growth,” Journal of Developmental Physiology, vol. 12, no. 4, pp. 173–182, 1989.
View at: Google Scholar
H. L. Miles, P. L. Hofman, and W. S. Cutfield, “Fetal origins of adult disease: a paediatric perspective,” Reviews in Endocrine and Metabolic Disorders, vol. 6, no. 4, pp. 261–268, 2005.
View at: Publisher Site | Google Scholar
A. L. Ogilvy-Stuart, S. J. Hands, and C. J. Adcock et al., “Insulin, insulin-like growth factor I (IGF-I), IGF-binding protein-1, growth hormone, and feeding in the newborn,” Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 10, pp. 3550–3557, 1998.
View at: Publisher Site | Google Scholar
J. Gardosi, A. Chang, B. Kalyan, D. Sahota, and E. M. Symonds, “Customised antenatal growth charts,” Lancet, vol. 339, no. 8788, pp. 283–287, 1992.
View at: Publisher Site | Google Scholar
J. Gardosi, M. Mongelli, M. Wilcox, and A. Chang, “An adjustable fetal weight standard,” Ultrasound in Obstetrics and Gynecology, vol. 6, no. 3, pp. 168–174, 1995.
View at: Publisher Site | Google Scholar
CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group, “CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women,” Lancet, vol. 343, no. 8898, pp. 619–629, 1994.
View at: Publisher Site | Google Scholar
J. Guevara-Aguirre, “Insulin-like growth factor I—an important intrauterine growth factor,” New England Journal of Medicine, vol. 335, no. 18, pp. 1389–1391, 1996.
View at: Publisher Site | Google Scholar
J. Verhaeghe, R. van Bree, E. van Herck, J. Laureys, R. Bouillon, and F. A. van Assche, “C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: correlations with birth weight,” American Journal of Obstetrics and Gynecology, vol. 169, no. 1, pp. 89–97, 1993.
View at: Google Scholar
L. C. Giudice, F. de Zegher, and S. E. Gargosky et al., “Insulin-like growth factors and their binding proteins in the term and preterm human fetus and neonate with normal and extremes of intrauterine growth,” Journal of Clinical Endocrinology and Metabolism, vol. 80, no. 5, pp. 1548–1555, 1995.
View at: Publisher Site | Google Scholar
E. Östlund, P. Bang, L. Hagenäs, and G. Fried, “Insulin-like growth factor I in fetal serum obtained by cordocentesis is correlated with intrauterine growth retardation,” Human Reproduction, vol. 12, no. 4, pp. 840–844, 1997.
View at: Google Scholar
H. Christou, J. M. Connors, and M. Ziotopoulou et al., “Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 2, pp. 935–938, 2001.
View at: Publisher Site | Google Scholar
C. Lassarre, S. Hardouin, F. Daffos, F. Forestier, F. Frankenne, and M. Binoux, “Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation,” Pediatric Research, vol. 29, no. 3, pp. 219–225, 1991.
View at: Google Scholar
W. A. Price, E. Lee, A. Maynor, A. D. Stiles, and D. R. Clemmons, “Relation between serum insulinlike growth factor-1, insulinlike growth factor binding protein-2, and insulinlike growth factor binding protein-3 and nutritional intake in premature infants with bronchopulmonary dysplasia,” Journal of Pediatric Gastroenterology and Nutrition, vol. 32, no. 5, pp. 542–549, 2001.
View at: Publisher Site | Google Scholar
J. M. Tanner, “Growth from birth to two: a critical review,” Acta Medica Auxologica, vol. 26, pp. 7–45, 1994.
View at: Google Scholar
R. P. Holmes, J. M. P. Holly, and P. W. Soothill, “Maternal serum insulin-like growth factor binding protein-2 and -3 and fetal growth,” Human Reproduction, vol. 14, no. 7, pp. 1879–1884, 1999.
View at: Publisher Site | Google Scholar
M. Chellakooty, K. Vangsgaard, and T. Larsen et al., “A longitudinal study of intrauterine growth and the placental growth hormone (GH)-insulin-like growth factor I axis in maternal circulation: association between placental GH and fetal growth,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 1, pp. 384–391, 2004.
View at: Publisher Site | Google Scholar
R. P. Holmes, J. M. P. Holly, and P. W. Soothill, “A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses,” British Journal of Obstetrics and Gynaecology, vol. 105, no. 12, pp. 1273–1278, 1998.
View at: Google Scholar
F. A. Hills, J. English, and T. Chard, “Circulating levels of IGF-I and IGF-binding protein-1 throughout pregnancy: relation to birth weight and maternal weight,” Journal of Endocrinology, vol. 148, no. 2, pp. 303–309, 1996.
View at: Publisher Site | Google Scholar
M. E. Fant and D. Weisoly, “Insulin and insulin-like growth factors in human development: implications for the perinatal period,” Seminars in Perinatology, vol. 25, no. 6, pp. 426–435, 2001.
View at: Publisher Site | Google Scholar
M. K. Bauer, J. E. Harding, and N. S. Bassett et al., “Fetal growth and placental function,” Molecular and Cellular Endocrinology, vol. 140, no. 1-2, pp. 115–120, 1998.
View at: Publisher Site | Google Scholar
F. P. Dominici, D. P. Argentino, M. C. Muñoz, J. G. Miquet, A. I. Sotelo, and D. Turyn, “Influence of the crosstalk between growth hormone and insulin signalling on the modulation of insulin sensitivity,” Growth Hormone and IGF Research, vol. 15, no. 5, pp. 324–336, 2005.
View at: Publisher Site | Google Scholar
M. S. Sandhu, A. H. Heald, J. M. Gibson, J. K. Cruickshank, D. B. Dunger, and N. J. Wareham, “Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study,” Lancet, vol. 359, no. 9319, pp. 1740–1745, 2002.
View at: Publisher Site | Google Scholar
Z. Ergaz, M. Avgil, and A. Ornoy, “Intrauterine growth restriction—etiology and consequences: what do we know about the human situation and experimental animal models?,” Reproductive Toxicology, vol. 20, no. 3, pp. 301–322, 2005.
View at: Publisher Site | Google Scholar
D. S. Fernandez-Twinn, S. E. Ozanne, and S. Ekizoglou et al., “The maternal endocrine environment in the low-protein model of intra-uterine growth restriction,” British Journal of Nutrition, vol. 90, no. 4, pp. 815–822, 2003.
View at: Publisher Site | Google Scholar
C. Martínez-Cordero, N. Amador-Licona, J. M. Guízar-Mendoza, J. Hernández-Méndez, and G. Ruelas-Orozco, “Body fat at birth and cord blood levels of insulin, adiponectin, leptin, and insulin-like growth factor-I in small-for-gestational-age infants,” Archives of Medical Research, vol. 37, no. 4, pp. 490–494, 2006.
View at: Publisher Site | Google Scholar
R. A. Bazaes, T. E. Salazar, and E. Pittaluga et al., “Glucose and lipid metabolism in small for gestational age infants at 48 hours of age,” Pediatrics, vol. 111, no. 4, part 1, pp. 804–809, 2003.
View at: Publisher Site | Google Scholar
V. Mericq, K. K. Ong, and R. Bazaes et al., “Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children,” Diabetologia, vol. 48, no. 12, pp. 2609–2614, 2005.
View at: Publisher Site | Google Scholar
K. K. Ong, C. J. Petry, and P. M. Emmett et al., “Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels,” Diabetologia, vol. 47, no. 6, pp. 1064–1070, 2004.
View at: Publisher Site | Google Scholar
A. Juul, “Determination of insulin-like growth factor I in children: normal values and clinical use,” Hormone Research, vol. 55, supplement 2, pp. 94–99, 2001.
View at: Publisher Site | Google Scholar
C. Löfqvist, E. Andersson, L. Gelander, S. Rosberg, W. F. Blum, and K. A. Wikland, “Reference values for IGF-I throughout childhood and adolescence: a model that accounts simultaneously for the effect of gender, age, and puberty,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 12, pp. 5870–5876, 2001.
View at: Publisher Site | Google Scholar
L. Bocconi, F. Mauro, and S. E. Maddalena et al., “Insulinlike growth factor 1 in controls and growth-retarded fetuses,” Fetal Diagnosis and Therapy, vol. 13, no. 3, pp. 192–196, 1998.
View at: Publisher Site | Google Scholar
R. Coutant, F. Boux de Casson, and O. Douay et al., “Relationships between placental GH concentration and maternal smoking, newborn gender, and maternal leptin: possible implications for birth weight,” Journal of Clinical Endocrinology and Metabolism, vol. 86, no. 10, pp. 4854–4859, 2001.
View at: Publisher Site | Google Scholar
E. Kajantie, L. Dunkel, and E.-M. Rutanen et al., “IGF-I, IGF binding protein (IGFBP)-3, phosphoisoforms of IGFBP-1, and postnatal growth in very low birth weight infants,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 5, pp. 2171–2179, 2002.
View at: Publisher Site | Google Scholar
E. Engström, A. Niklasson, K. A. Wikland, U. Ewald, and A. Hellström, “The role of maternal factors, postnatal nutrition, weight gain, and gender in regulation of serum IGF-I among preterm infants,” Pediatric Research, vol. 57, no. 4, pp. 605–610, 2005.
View at: Publisher Site | Google Scholar
V. Barrios, J. Argente, and J. Pozo et al., “Insulin-like growth factor I, insulin-like growth factor binding proteins, and growth hormone binding protein in Spanish premature and full-term newborns,” Hormone Research, vol. 46, no. 3, pp. 130–137, 1996.
View at: Google Scholar

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Copyright © 2007 Ariadne Malamitsi-Puchner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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