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Mediators of Inflammation
Volume 2007 (2007), Article ID 45794, 5 pages
http://dx.doi.org/10.1155/2007/45794
Clinical Study

Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease

1Department of Nutrition, Federal University of Santa Catarina, Florianópolis, SC 88040-970, Brazil
2Department of Ecology and Zoology, Federal University of Santa Catarina, Florianópolis, SC 88040-970, Brazil
3Department of Clinical Analysis, Federal University of Santa Catarina, Florianópolis, SC 88040-970, Brazil

Received 31 January 2007; Revised 23 May 2007; Accepted 25 May 2007

Copyright © 2007 Ivan Borges Jr. et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis. Subject and methods. Eighteen subjects were divided in two groups: experimental (age 52.9±5.0) and control (age 51.1±9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Student t test and P<.05. Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05). Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.