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Mediators of Inflammation
Volume 2007, Article ID 53921, 5 pages
Research Article

Perinatal Changes of Cardiac Troponin-I in Normal and Intrauterine Growth-Restricted Pregnancies

1Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens 10682, Greece
2Research Laboratories, 2nd Department of Paediatrics, Athens University Medical School, Athens 10682, Greece

Received 21 April 2007; Accepted 21 May 2007

Copyright © 2007 Nicoletta Iacovidou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Intrauterine growth restriction (IUGR) implies fetal hypoxia, resulting in blood flow redistribution and sparing of vital organs (brain, heart). Serum cardiac Troponin-I (cTnI), a well-established marker of myocardial ischaemia, was measured in 40 mothers prior to delivery, the doubly clamped umbilical cords (representing fetal state), and their 20 IUGR and 20 appropriate-for-gestational-age (AGA) neonates on day 1 and 4 postpartum. At all time points, no differences in cTnI levels were observed between the AGA and IUGR groups. Strong positive correlations were documented between maternal and fetal/neonatal values (r.498, P.025 in all cases in the AGA and r.615, P.009 in all cases in the IUGR group). These results may indicate (a) normal heart function, due to heart sparing, in the IUGR group (b) potential crossing of the placental barrier by cTnI in both groups