Plasma Interleukin-18 and Dendritic Cells in Males with Psoriasis Vulgaris

Pietrzak, Aldona; Janowski, Konrad; Chodorowska, Grażyna; Michalak-Stoma, Anna; Rolinski, Jacek; Zalewska, Anna; Jastrzebska, Iwona; Tabarkiewicz, Jacek; Paszkowski, Tomasz; Kapec, Ewa; Krasowska, Dorota

doi:https://doi.org/10.1155/2007/61254

Mediators of Inflammation

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Clinical Study | Open Access

Volume 2007 | Article ID 061254 | https://doi.org/10.1155/2007/61254

Plasma Interleukin-18 and Dendritic Cells in Males with Psoriasis Vulgaris

Aldona Pietrzak,¹Konrad Janowski,²Grażyna Chodorowska,¹Anna Michalak-Stoma,³Jacek Rolinski,³Anna Zalewska,⁴Iwona Jastrzebska,³Jacek Tabarkiewicz,³Tomasz Paszkowski,⁵Ewa Kapec,⁵and Dorota Krasowska¹

Received18 Dec 2006

Accepted12 Feb 2007

Published05 Apr 2007

Abstract

Peripheral blood dendritic cells seem to play a crucial role in psoriatic inflammatory processes. The aim of our study is to investigate the relationship between plasma interleukin-18 (IL-18) levels and blood dendritic cells in psoriatic patients. IL-18 plasma levels were measured by ELISA. Phenotypes of dendritic cell subsets were analyzed by double-colour flow cytometry. Plasma IL-18 level in psoriatic males was significantly higher, whereas counts of BDCA-2+ cells were lower than in the control group. The myeloid/plasmacytoid ratio was significantly higher in the patient group compared to the control one. In the patient group, significant negative correlations between plasma IL-18 level and both the BDCA-1+ and BDCA-2+ counts were found. BDCA-1+ counts correlated negatively with percentage of skin involvement. IL-18 seems to play a role in psoriasis pathogenesis. The decreased counts of blood plasmacytoid DCs in psoriatic patients might result from IL-18 down-regulation of plasmacytoid DC precursor proliferation.

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Copyright © 2007 Aldona Pietrzak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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