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Mediators of Inflammation
Volume 2007, Article ID 81838, 6 pages
http://dx.doi.org/10.1155/2007/81838
Clinical Study

The Immunohistochemistry Profile of Lymphocytic Gastritis in Celiac Disease and Helicobacter Pylori Infection: Interplay between Infection and Inflammation

1Institute of Gastroenterology, Assaf Harofeh Medical Center, Sackler School of Medicine, University of Tel-Aviv, Zerifin 70300, Israel
2Institute of Pathology, Assaf Harofeh Medical Center, Sackler School of Medicine, University of Tel-Aviv, Zerifin 70300, Israel
3Pediatric Gastroenetrology and Nutrition Unit, Carmel Medical Center, Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa 32000, Israel

Received 10 July 2007; Accepted 24 September 2007

Copyright © 2007 Efrat Broide et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lymphocytic gastritis (LG) is associated with helicobacter pylori (Hp) and celiac disease (CD). We aimed to clarify the relationship between Hp infection and CD by defining a unique histopathology profile of LG in these two diseases. Forty patients who underwent upper endoscopy were divided into four groups: eight controls, ten active CD patients without Hp, twelve CD negative with Hp, and ten active CD with Hp infection. Antral samples were assessed by immunohistochemical staining for CD20, CD3, CD4, CD8, CD57, CNA42, and Ki67 for lymphoid aggregates, intraepithelial lymphocytes (IELs) number, density of lamina propria (LP) lymphocytes, and inflammatory glandular involvement. Only IELs positive for CD3 and CD8 were increased significantly in CD patients with or without Hp infection. Hp did not contribute to the number of CD8 IELs. In complicated cases with Hp and suspicious for CD, the number of CD8+ IELs hints toward a CD rather than Hp infection.