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Mediators of Inflammation
Volume 2007, Article ID 93573, 8 pages
Research Article

Association of C-Reactive Protein, Interleukin-1 Receptor Antagonist and Adiponectin with the Metabolic Syndrome

1Department of Internal Medicine, Central Hospital of Middle Finland, Jyväskylä 40620, Finland
2Department of General Medicine, Central Hospital of Middle Finland, Jyväskylä 40620, Finland
3Laukaa Health Center, Laukaa 41341, Finland
4Medcare Foundation, Äänekoski 44100, Finland
5Department of Public Health and Clinical Nutrition, University of Kuopio, Kuopio 70211, Finland
6Unit of General Practice, Kuopio University Hospital, Kuopio 70211, Finland
7Department of Medicine, University of Kuopio, Kuopio 70211, Finland

Received 6 July 2007; Accepted 29 August 2007

Copyright © 2007 Juha Saltevo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This Finnish population-based study, mean age 46 years, evaluates the association of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 receptor antagonist (IL-1Ra), and adiponectin with the NCEP and IDF definitions of metabolic syndrome (MetS). Adiponectin levels were higher, hs-CRP and IL-1Ra levels lower in subjects without MetS compared to subjects with MetS. If MetS was present according to both IDF and NCEP criteria, BMI, waist, triglycerides, hs-CRP, and IL-1Ra were significantly higher compared to subjects who had MetS according to either only IDF or only NCEP criteria. The hs-CRP, IL-1Ra, and adiponectin linearly correlated with the number of the components of MetS according to both definitions. Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of MetS. Individuals who had MetS according to both criteria had the most adverse changes in cardiovascular risk factors.