Increased Responsiveness to Toll-Like Receptor 4 Stimulation in Peripheral Blood Mononuclear Cells from Patients with Recent Onset Rheumatoid Arthritis

Table 2

Spontaneous and stimulated IL-6 production by peripheral blood mononuclear cells from patients with rheumatoid arthritis (RA), osteoarthrosis(OA), and healthy controls (HC); median values; 𝑃<.05^∗—significantly different from nonstimulated; #—significant difference between RA and HC ∧—significant difference between RA and OA.

	Nonstimulated	Stimulus
		LPS 1 ng/mL	LPS 10 ng/mL	LPS 100 ng/mL	BGN 0,1 ng/mL	BGN1# ng/mL	BGN#10 ng/mL
Group of subjects	concentration of IL-6 (ng/mL)
RA	0,56#⋀	22,87∗	42,95∗⋀	46,72∗	2,0⋀	1,24#⋀	1,55#⋀
OA	27,2	43,6∗	88,47∗	75,1∗	22,6	33,01	23,0
HC	25,45	86,46∗	73,47	99,11∗	21,15∗	50,81	46,0