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Mediators of Inflammation
Volume 2008 (2008), Article ID 135625, 4 pages
http://dx.doi.org/10.1155/2008/135625
Review Article

Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes

Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, Rome 00168, Italy

Received 17 October 2007; Accepted 21 January 2008

Academic Editor: Rod J. Flower

Copyright © 2008 Valentina Loria et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).