Circulating Tissue Inhibitor of Matrix Metalloproteinase-4 (TIMP-4) in Systemic Sclerosis Patients with Elevated Pulmonary Arterial Pressure

Table 3

Age-adjusted partial correlations (𝑟) of MMP-9, TIMP-4 and their ratio with respiratory and cardiac indicators in 106 patients with systemic sclerosis. Levels of significance are shown in parentheses.

	MMP-9	Log10(TIMP-4)	Log10(MMP-9/TIMP-4)
Pulmonary function tests
FEV1 (%predicted)	−0.14 (NS)	−0.09 (NS)
FVC (%predicted)	−0.14 (NS)	−0.14 (NS)
TLC (%predicted)	−0.16(𝑃=.070)	−0.09 (NS)
DLCO (%predicted)	−0.19(𝑃=.068)	−0.70 (NS)
Cardiac parameters
PASP	0.02 (NS)	0.29 (𝑃=0.021)
log10 (BNP)	0.00 (NS)	0.19 (NS)
RV Tei Index	0.02 (NS)	0.15 (NS)
LV Tei Index	−0.23(𝑃=.046)	0.17 (NS)
LV EF (%)	0.07 (NS)	−0.15 (NS)

FEV1: forced expiratory volume at 1 second;FVC: forced vital capacity;TLC: total lung capacity;DLCO: diffusing lung capacity for carbon monoxide;PASP: pulmonary artery systolic pressure;BNP: B-type natriuretic peptide;RV: right ventricular;LV: left ventricular;EF: ejection fraction;NS denotes nonsignificant.