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Mediators of Inflammation
Volume 2008, Article ID 186584, 7 pages
http://dx.doi.org/10.1155/2008/186584
Clinical Study

Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors

1Research Institute of Oncology (IPON), Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil
2Discipline of Human Anatomy, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil
3Discipline of Pharmacology, Federal University of Triângulo Mineiro, 38015-050 Uberaba, MG, Brazil
4Discipline of Special Pathology, Federal University of Triângulo Mineiro, 38025-440 Uberaba, MG, Brazil

Received 12 August 2008; Revised 16 October 2008; Accepted 12 November 2008

Academic Editor: Jan van Amsterdam

Copyright © 2008 Rosekeila Simões Nomelini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tumor sections from nonneoplastic ( ), benign ( ), and malignant ovarian tumors ( ) were obtained from 63 women. Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples. Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples ( ). For stage I ovarian cancer, intracystic NO levels were more frequent than NO levels , and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas ( ). These data suggest an important role for NO in ovarian carcinogenesis.