MCP-1 −𝟐𝟓𝟏𝟖 A/G Single Nucleotide Polymorphism in Slovak Patients with Systemic Sclerosis

Table 2

Genotype, allele, and phenotype (carriage rates) frequencies of the MCP-1 −2518 SNP in Slovak patients with systemic sclerosis and healthy controls compared with the data from German population according to the study by Karrer et al. [13].

Frequency	Genotype			Allele		Phenotype
	AA	AG	GG	A	G	A	G
Slovak patients (𝑛=46)	63.0 (29)	28.3 (13)	8.7∗ (4)	77.2 (71)	22.8^+ (21)	91.3 (42)	37.0^# (17)
Slovak controls (𝑛=449)	57.5 (258)	36.7 (165)	5.8 (26)	75.8 (681)	24.2^† (217)	94.2 (423)	42.5 (191)
German patients (𝑛=18)	44.4 (8)	27.8 (5)	27.8^§ (5)	58.3 (21)	41.7 (15)	72.2 (13)	55.6 (10)
German controls (𝑛=139)	51.1 (71)	42.4 (59)	6.5 (9)	72.3 (201)	27.7 (77)	93.5 (130)	48.9 (68)

Data are given as proportions (%) of particular genotype/allele/phenotype with their absolute number in parentheses. P values for comparison of allele, genotype, and phenotype frequencies between the Slovak SSc patients and controls: ⁺𝑃=.81;^∗𝑃=.67;^#𝑃=.51. P value for comparison of GG genotype frequencies between the German SSc patients and controls [13]: ^§𝑃=.02. P value for comparison of G allele frequencies between the Slovak and German control subjects [13]: ^†𝑃=.23.