Inhibition of Angiogenic Factor Production from Murine Mast Cells by an Antiallergic Agent (Epinastine Hydrochloride) In Vitro
Figure 1
Suppressive activity of epinastine hydrochloride (EP) on angiogenic factor production from
mast cells in IgE-dependent mechanism. Murine peritoneal mast cells ( cells/mL) sensitized with IgE specific for ovalbumin (OVA) were stimulated with
10 ng/mL OVA in the presence of various concentrations of EP for 4 hours. The
levels of angiogenic factors in culture supernatants were analyzed by ELISA.
The data were expressed as the mean pg/mL ± SE of triplicate cultures. KC: keratinocyte-derived chemokine (a); TNF: TNF-α (b);
VEGF: vascular endothelial growth factor (c);
* versus control (EP at 0 ng/mL).
