Inhibition of Angiogenic Factor Production from Murine Mast Cells by an Antiallergic Agent (Epinastine Hydrochloride) In Vitro
Figure 2
Influence of epinastine hydrochloride (EP) on angiogenic factor release from mast cells in
IgE-dependent mechanism. Murine peritoneal mast cells ( cells/mL) sensitized with IgE specific for ovalbumin (OVA) were stimulated with
10 ng/mL OVA. After 4 hours, cells were
collected, sonically disrupted, and the levels of angiogenic factors in
cytosole were examined by ELISA. The data are expressed as the mean pg/mL ± SE
of triplicate cultures. KC: keratinocyte-derived chemokine
(a); TNF: TNF- (b); VEGF: vascular endothelial growth factor (c);
*
versus control (EP at 0 ng/mL).
