The NF-B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis
Figure 6
Treatment of incubated muscles from septic rats with curcumin inhibits 20S proteasome and calpain activity but does not influence cathepsin L activity. Extensor digitorum longus muscles were harvested from rats 16 hours after CLP and incubated for 2 hours in the absence
or presence of curcumin (100 M) followed by measurement of (a) 20S proteasome activity, (b) calpain activity, and (c) cathepsin L activity as described in Section 2. Results are means ±SEM with in each group. FU: fluorogenic units. * versus control by Student’s -test.
