The NF-𝜅B Inhibitor Curcumin Blocks Sepsis-Induced Muscle Proteolysis

Table 1

The effects of curcumin on protein breakdown by different proteolytic pathways in incubated EDL muscles from septic rats. EDL muscles from septic rats were incubated in the absence or presence of specific proteolytic inhibitors. The inhibition of protein degradation caused by an inhibitor was calculated as the portion of protein degradation regulated by that specific proteolytic pathway. All differences caused by the proteolytic inhibitors as well as all differences induced by curcumin were statistically significant 𝜇 by ANOVA. Results are means ±SEM with 𝜇 in each group.

Inhibitor	Protein degradation (nmol tyr/g ww 𝜇 h)		Inhibition by curcumin
	No curcumin	Curcumin
No addition	𝜇	𝜇
-lactone (100 M)	𝜇	7×8
Proteasomal degradation	66	36	−45%
No addition	×3	𝜅
Calpeptin (100 M)	𝛼	×3
Calpain-dependent degradation	75	37	−51%
No addition	𝜅	𝜅
Cathepsin L Inhibitor IV (100 M)	𝜅	𝜅
Lysosomal degradation	114	65	−43%