Effects of Nebivolol on Endothelial Gene Expression during Oxidative Stress in Human Umbilical Vein Endothelial Cells
Table 1
Effect of nebivolol and
atenolol on protein expression of adhesion molecules (ICAM-1, ICAM-2, ICAM-3,
E-selectin, P-selectin), proteins linked to inflammation (IL-6, TNFalpha), and
thrombotic state (tissue factor, uPA, PAI-1), endothelin-1 (ET-1),
metalloproteinases (MMP-2, MMP-9), and protease inhibitor (TIMP-1) induced by
oxidative stress in endothelial cells.
oxLDL
Nebivolol
Nebivolol+oxLDL
Atenolol
Atenolol+oxLDL
ICAM-1 (%)
175+19*
98±11
126±17*†
99±12
162±21*
ICAM-2 (%)
197±28*
95±13
123±25*†
98±15
191±32*
ICAM-3
(%)
152±26*
103±16
113±18*†
101±16
140±24*
E-selectin (%)
183+25*
99±16
137±21*†
102±15
180±23*
P-selectin (%)
245±29*
102±14
179±25*†
99±17
236±27*
IL-6 (%)
335±39*
98±16
180±21*†
97±16
341±37*
TNFalpha (%)
378±46*
100±15
221±31*†
102±14
366±48*
TF (%)
196±27*
99±15
149±21*†
100±17
199±30*
u-PA
(%)
189±24*
99±16
140±25*†
98±12
191±27*
PAI-1
(%)
203±30*
101±15
179±25*†
98±15
236±27*
ET-1 (%)
275±32*
97±13
163±25*†
101±16
266±35*
MMP2 (%)
287±36*
99±13
161±21*†
100±15
296±39*
MMP9 (%)
216±29*
101±11
161±19*†
99±13
205±27*
TIMP-1
(%)
737±96*
102±13
459±65*†
99±12
721±88*
Legend: data are and
are expressed as % increase versus control; versus control; † versus oxLDL.
