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Mediators of Inflammation
Volume 2008 (2008), Article ID 407972, 9 pages
http://dx.doi.org/10.1155/2008/407972
Clinical Study

Homocysteine May Involve in the Pathogenesis of Behcet's Disease by Inducing Inflammation

1Department of Dermatology, Diskapi Yildirim Beyazit Education and Research Hospital, Ministry of Health Ankara, 06110 Ankara, Turkey
2Department of Cardiovascular Surgery, Turkiye Yuksek Ihtisas Education and Research Hospital, Ministry of Health Ankara, 06100 Ankara, Turkey

Received 1 August 2008; Revised 2 November 2008; Accepted 17 November 2008

Academic Editor: Dennis Daniel Taub

Copyright © 2008 Selda Pelin Kartal Durmazlar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. Methods. Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF- 𝛼 ), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were evaluated with respect to activity and specific individual clinical manifestations of the disease. Results. Hcy levels were found significantly elevated in active BD when compared to inactive BD and healthy controls. Hcy levels were found to have high correlation with the number of active clinical manifestations increased. A significant positive correlation was found between serum Hcy and TNF- 𝛼 levels, CRP, and ESR. Hcy was found to be the best predictor of TNF- 𝛼 among other parameters. Conclusion. Hcy may involve in the pathogenesis of BD by inducing inflammation.